Di-tert-butyl-dicarbonate
--- a new kind of security amino acid protective agent
Di-tert-butyl-dicarbonate£¨CAS:24429-99-5£©,alternative name is BOC,short name:DI-BOC,which is used in the organic synthesis to introduce tert-Butoxycarbonyl protection gene,especially used in amino acid protective.Widely used in pharmaceutical,protein and polypeptide compound¡¢biology food¡¢cosmetics and so on.
Compared with the traditional amino acid protecting agent like benzyl chloroformate, chloroformate - P carboxyliacid, it is more safe,more economical, more efficient and easier to control.
Tell from safety, to synthesize a kind of compound same with natural peptide, must take all sorts optical rotation of amino acids in a certain sequence linked to certain length of peptide, need to make combination of a kind of amino acid in the carboxyl and another kind of amino acid in the amino, it should prevent the same kinds of amino acids combined, therefore, it must have the certain amino or carboxyl protected when compound, so that reaction can be proceed according to requirements.
Di-tert-butyl-dicarbonate plays the best role in this aspect. Besides,di-tert-butyl-dicarbonate is without strong sharp taste, non-toxic effect, but can cause irritation if directly contact with skin.When use this product to synthe peptide,to protect removal of gene in normal conditions,good product of purification reaction than using other types of amino acid protectants are easy.
Tell from the economy, in recent years as the preparation methods and technology innovation,of DI-BOC make the process easy, which greatly reduce the cost of product, and market price descend to low levels. Danyang jinxiang chemical factory is the earliest manufacturer to develop the new process of Di-boc, after five years of hard working to get a breakthrough in its preparation methods and process.And got the patent in 2006.8.30. And after another five years of a large scale production and practice accumulation, makes the di-boc reach to a new height in product quality, production safety, product yield.Especially in recent two years,due to the further optimization for the raw materials,the contamination to the environment is almost zero during the production.
Market is the best examiner of product.Di-tert-butyl-dicarbonate produced by jinxiang chemical factory has been accepted by some big international pharmaceutical enterprises, and form a strategic cooperation supplier.By the end of 2010, jinxiang shares 87% markets of Europe, America, India and have more than 60% customers in domestic market. So far the qualified rate of Di-tert-butyl-dicarbonate supply from Jinxiang is up to 99%,and customers satisfaction is to be 100%.
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