General description and applications of 4'-Hydroxyacetophenone£¨CAS No:99-93-4)

4'-Hydroxyacetophenone is an important intermediate of synthesis selective B l receptor blocker atenolol (#1),cas no. 99-93-4.

4'-Hydroxyacetophenone, the simplest aromatic ketone, is a white crystal powder, melting point 108-110 ¡æ,boiling point 147¡æ£¨0.40kPa),very slightly soluble in water.

Commercial acetophenone can be obtained from benzene with acetic anhydride or acetyl chloride by Friedel-Crafts process. It can be also obtained by air oxidation of ethylbenzene, as a by-product of cumene or from acrylonitrile. That can be used as follows:
1.a polymerization catalyst for the manufacture of olefins.
2.an intermediate for pharmaceuticals, agrochemicals and other organic compounds.
3.a drug to induce sleep.
4. an solvent for plastics, resins, cellulose ethers, and esters.
5. used in tear gas (especially as the form of chloro acetophenone) and warfare.

The dimer (dipnone) is used as a plasticizer. Actophenone and its derivatives, having additionally substituted saturated alkyls, oxygenated alkyl groups, thio groups, additional aromatic groups, unsaturated aliphatic side chains, and other functional groups, are ingredients of flavor & fragrance for in soaps, detergents, cosmetics, and perfumes as well as in foods, beverages, and tobacco.
Hydroxyacetophenone, known as cas no:99-93-4, is used as building block or the synthesis of rubbers, plastics, pharmaceuticals, agrochemicals and flavor and fragrances (odor: Sweet, heavy floral).